In recent years, nattokinase red yeast rice has gained popularity. But how do you choose the right nattokinase red yeast rice product? The Health and Medical Institute has compared 4 major aspects of commercially available nattokinase red yeast rice products for you! This will help you make an informed choice when selecting suitable nattokinase red yeast rice dietary supplements.
4 Key Considerations for Selecting Nattokinase Red Yeast Rice Products
Cardiovascular disease remains one of the leading causes of death worldwide, and current medical approaches to managing its mortality rates are limited. Numerous studies have indicated that nattokinase, an active component found in natto (fermented soybeans), has various beneficial cardiovascular effects. It has been linked to a reduction in the risk of cardiovascular disease-related deaths[1].
💡Nattokinase has also been found in other research to improve conditions such as hypertension, Alzheimer’s disease, atherosclerosis, and the protection of nerve function[2].
Red yeast rice, commonly consumed in Asian regions, contains an active component called Monacolin K. Research suggests that Monacolin K can lower cholesterol levels and improve endothelial function. It is suitable for individuals with mild to moderate hypercholesterolemia[3][4]. Nowadays, it is also available as a dietary supplement for cardiovascular health.
Due to these health-promoting functions, the market is flooded with nattokinase red yeast rice supplements. How do you choose the right product that suits your needs and supports cardiovascular health? Here are 4 key points to consider:
1. Nattokinase Requires an Effective Dosage
Nattokinase is an enzyme produced by Bacillus subtilis natto, and it exhibits high fibrinolytic activity, which is beneficial for improving atherosclerosis[1]. Its activity is measured in Fibrin Degradation Units (FU) due to its fibrinolytic nature. For health-promoting effects, it is generally recommended to consume at least 2000 FU per day[5]. The Nattokinase Association of Japan also suggests a minimum daily intake of 2000 FU for effectiveness[6].
💡In a clinical study, subjects were given a daily dosage of 4000 FU of nattokinase for two months. The results showed that nattokinase could reduce the risk of cardiovascular disease by regulating clotting factors[7].
💡Another study found that a daily intake of 4000 FU of nattokinase for eight weeks led to a significant reduction in total cholesterol and low-density lipoprotein cholesterol (LDL-C)[8].
💡In another study, subjects were given high-dose nattokinase (over 5000 FU) or simvastatin (a cholesterol-lowering drug). The study found comparable cholesterol-lowering effects between the nattokinase and simvastatin groups, with no observed adverse reactions[9].
When selecting a nattokinase product, look for the indicated FU activity of nattokinase rather than just the natto extract content. For those aiming to improve cardiovascular health, products with higher nattokinase FU activity are preferable.
Further Reading: The Many Benefits of Natto: Experts Introduce You to “Nattokinase” and its Side Effects (This Point Must Not Be Overlooked!)
2. Nattokinase Combined with Red Yeast Rice for Enhanced Cholesterol Reduction
The Monacolin K found in red yeast rice shares similarities in metabolic pathways with Lovastatin, a cholesterol-lowering drug. Monacolin K is the primary substance in red yeast rice that helps regulate cholesterol levels[3].
💡In a clinical study, subjects with high cholesterol were given daily red yeast rice supplements containing 11.4 mg of Monacolin K. After eight weeks, total cholesterol was significantly reduced by 20.4%, and LDL-C was reduced by 26.3%, suggesting an improvement in lipid profile and cardiovascular health[10].
💡Another study divided hyperlipidemic patients into groups that either consumed nattokinase alone or a combination of nattokinase and red yeast rice. The group that consumed both showed more significant reductions in triglycerides, total cholesterol, and LDL-C compared to the nattokinase-only group, indicating that combining nattokinase with red yeast rice results in better lipid-lowering effects[11].
The European Food Safety Authority suggests that Monacolin K should be consumed in doses of at least 10 mg daily over an extended period to effectively improve cholesterol levels[3]. Consumers should pay attention to the Monacolin K content when choosing products[12].
3. CoQ10 Supplementation with Nattokinase Supports Cardiovascular Health
Coenzyme Q10 (CoQ10), also known as ubiquinone, is an essential nutrient for the body. Its physiological functions mainly involve energy metabolism in mitochondria. CoQ10 also possesses excellent antioxidant capabilities and is present in various tissues, including cell membranes.
CoQ10 is a lipophilic antioxidant synthesized in the body. Deficiencies in CoQ10 have been linked to several neurodegenerative diseases, diabetes, cancer, fibromyalgia, muscle disorders, and cardiovascular diseases[13]. However, when supplementing with nattokinase (containing Monacolin K), the synthesis of CoQ10 is inhibited in metabolic pathways, leading to reduced CoQ10 levels in the body[14].
💡In a clinical study, subjects were given 10 mg of Monacolin K and 30 mg of CoQ10 daily for four weeks. The results showed protective effects on vascular endothelial cells and a reduction in arterial stiffness[15].
4. Testing and Inspection Are Indispensable
Aflatoxins, produced primarily by Aspergillus flavus and parasitic fungi, are known for their hepatotoxic, carcinogenic, and teratogenic properties. Moreover, aflatoxins are heat-resistant and cannot be removed from food even through cooking. Improper handling or storage of cereals, nuts, and legume products can lead to aflatoxin contamination[17].
In addition, for red yeast rice-related products, the concentration of Citrinin should be less than 2 ppm (parts per million)[12]. Citrinin is a mycotoxin with hepatotoxic and nephrotoxic properties. Prolonged consumption can negatively impact liver and kidney function and even cause fetal malformation[18].
When choosing nattokinase red yeast rice products, factors such as pesticide residues, heavy metal contamination, and plasticizers are essential aspects of product quality. These products are often consumed over an extended period, making safety and quality crucial considerations.
【2023】Top 6 Natto Red Yeast Rice Comprehensive Rankings
Our team has gathered and evaluated 6 popular Natto Red Yeast Rice products available in the market, providing the following relevant information for your reference:
1. Daiken Q10-Natto Plus Red Yeast Rice Complex
- With or without citrinin test: yes
- Coenzyme Q10: 30 mg/2 capsules
- Nattokinase content: 5000FU/2 capsules
- Red yeast rice: Monacolin K 15mg/2 capsules
- View Product >
2. LAC Activated NATTOCARE With CoQ10
- Whether there is citrinin test: not disclosed
- Coenzyme Q10: 30 mg/2 capsules
- Nattokinase content: 3920FU/2 capsules
- Red yeast rice: Monacolin K 10mg/2 capsules
- View Product >
3. Chang Gung Biotechnology Natto – Monascus
- Whether there is citrinin test: not disclosed
- Coenzyme Q10: No
- Nattokinase content: 4000FU/4 capsules
- Red yeast rice: Monacolin K 10mg/4 capsules
- View Product >
4. WeiDer Natto Red Yeast Rice
- Whether citrinin test: not marked
- Coenzyme Q10: No
- Nattokinase content: 3000FU/2 capsules
- Red yeast rice: Monacolin K 7mg/2 capsules
- View Product >
5. Niang Jia Red Yeast Rice
- Whether there is citrinin test: not disclosed
- Coenzyme Q10: No
- Nattokinase content: no
- Red yeast rice: Monascin 2.84~4.2mg/1 grain, Ankaflavin 1.28~1.92 mg/1 grain
- View Product >
6. Grape King Bio Natto Red Yeast Rice
- Whether there is citrinin test: not disclosed
- Coenzyme Q10: yes, dosage not indicated
- Nattokinase content: 2400FU/2 capsules
- Red yeast rice: not marked
- View Product >
Compare Table of 6 Natto Red Yeast Rice
| Rank | 1 | 2 | 3 | 4 | 5 | 6 |
| Product | Daiken Q10-Natto Plus Red Yeast Rice Complex | LAC Activated NATTOCARE With CoQ10 | Chang Gung Biotechnology Natto – Monascus | WeiDer Natto Red Yeast Rice |
Niang Jia Red Yeast Rice | Grape King Bio Natto Red Yeast Rice |
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|
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| With or without citrinin test | yes | not disclosed | not disclosed | not disclosed | not disclosed | not disclosed |
| Coenzyme Q10 | 30mg/2 capsules | 30mg/2 capsules | No | No | No | yes, dosage not indicated |
| Nattokinase content | 5000FU/2 capsules | 3920FU/2 capsules | 4000FU/4 capsules | 3000FU/2 capsules | No | 2400FU/2 capsules |
| Red yeast rice | Monacolin K 15mg/2 capsules | Monacolin K 10mg/2 capsules | Monacolin K 10mg/4 capsules | Monacolin K 7mg/2 capsules | Monascin 2.84~4.2mg/1 capsule Ankaflavin 1.28~1.92 mg/1 capsule |
not marked |
Summary
The prevalence of disabilities and deaths caused by cardiovascular diseases continues to rise each year, highlighting the importance of daily health maintenance. Health-related nutrients such as nattokinase, red yeast rice, and coenzyme Q10 offer a wealth of abundant and safe research information. This information serves as a valuable reference for individuals when selecting products aimed at preventing cardiovascular diseases. Making informed choices based on this research ensures that individuals choose products that are not only effective but also safe for their health.
