What is UC2? Expert explanation of UC2 benefits and side effects (3 times the efficacy of glucosamine!)

UC2 is a patented form of non-denatured type II collagen derived from chicken sternum. It primarily serves as a novel therapeutic tool for symptoms of joint inflammation, osteoarthritis, and rheumatoid arthritis. It has also gained popularity as an emerging health supplement formula in recent years. Does it really have its efficacy in research? And how does it compare to glucosamine? Let’s delve into the following introduction.

What is UC2?

The commonly heard term UC2/UCII refers to undenatured type II collagen (UC-II®), which is a patented form of non-denatured type II collagen derived from chicken sternum. It has become a popular ingredient in joint health in recent years. While glucosamine has been well-known in the realm of joint health supplements, UC2/UCII gained prominence as a new favorite in bone and joint health after its research was published[1].

In small doses, UC-II® has shown significant pain relief for patients with noticeable joint pain. This includes alleviating morning stiffness, stiffness after rest, intensified pain during joint use, and loss of joint mobility and function. It can be considered a novel therapeutic tool for symptoms of joint inflammation, osteoarthritis, and rheumatoid arthritis.


What are the benefits of UC2?

Improving Osteoarthritis

Early studies suggest that taking a specific product containing type II collagen, MSM, cetyl myristoleate, enzymes, vitamin C, turmeric, and bromelain may reduce joint pain and tenderness in osteoarthritis patients when taken orally for 12 weeks.

Clinical trials have also demonstrated the therapeutic effects of natural type II collagen in treating knee osteoarthritis[2][3] [4].


Relieving Rheumatoid Arthritis Pain

Some research indicates that autoimmune diseases like rheumatoid arthritis can be treated using oral administration of antigens, a method known as “oral tolerance,” which aims to suppress the immune system’s response. Studies show that oral intake of type II collagen can reduce swelling and the number of tender joints in rheumatoid arthritis patients[5] [6].


Assisting in Bone Density Enhancement:

UC2/UCII non-denatured type II collagen can aid in mineralization of bones and reduce the production of inflammatory cytokines. By decreasing oxidative stress, it can contribute to increasing bone density, thus positively impacting bone health.


What are the symptoms of lacking UC2/UCII type II collagen?

The source of UC2/UC-II non-denatured type II collagen is extracted from chicken breast cartilage using a low-temperature process. Therefore, if there are joint pain or inflammation issues, it’s recommended to prioritize supplementing with UC2/UC-II for improvement and joint health.

Type II collagen primarily exists in cartilage. If lacking in type II collagen, it may lead to cartilage atrophy and deformation issues. Additionally, the absence of lubricating cartilage can result in bone-on-bone friction, causing discomfort and pain.


Are there any side effects of supplementing with UC2?

UC2/UCII is a type of protein, so moderate supplementation is generally safe. However, some individuals might experience mild stomach discomfort, headaches, difficulty sleeping, dizziness, or liver issues, though these side effects are uncommon.

For individuals who are pregnant or breastfeeding, there is currently insufficient reliable information to determine the safety of using type II collagen, so it’s advisable to avoid using it.

People with allergies to chicken or eggs should also exercise caution when supplementing with type II collagen, as collagen products can be related to allergic reactions.


Is UC2/UC-II present in foods?

Collagen in food is typically sourced from items like pig’s feet or chicken feet, and these forms of collagen are often larger molecules that are less easily absorbed. Moreover, such foods can be calorie-dense. While these sources do contain collagen, type II collagen (UC2/UC-II) primarily exists in cartilage. It’s challenging to consume significant amounts of cartilage-containing foods in everyday diets. As a result, achieving the research-recommended intake for joint support through dietary sources alone, particularly UC2/UC-II, can be difficult.


When and how much UC2 to take for beneficial effects?

A daily dose of around 40 milligrams is commonly used for treating osteoarthritis and rheumatoid arthritis. It’s best taken on an empty stomach before breakfast.

The correct dosage for any supplement depends on various factors including age, gender, health condition, genetics, and lifestyle. Always follow the instructions provided on the product label and consult a pharmacist, doctor, or other healthcare professional before use.


What ingredients can consume with UC2?

UC2/UC-II is commonly taken by individuals who seek to improve and maintain joint health. It’s recommended to supplement UC2/UC-II along with other ingredients such as hyaluronic acid, turmeric, and MSM (Methyl-Sulfonyl-Methane). Hyaluronic acid helps with joint lubrication, turmeric has anti-inflammatory effects, and MSM is an organic sulfur compound that plays a crucial role in joint rebuilding processes and helps strengthen ligaments and soft tissue structures. When selecting a type II collagen product, consider formulations that include these complementary ingredients to effectively alleviate joint pain and restore mobility.


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